Whenever I go to a new city I immediately look up the local used and rare bookstores...
The New York Times has an interesting Travel Page article about Book Tourism in the Massachusetts area... See Link.
I'll be in Denver for Thanksgiving week, and I'm planning on hitting the "Book District" at Broadway and 1st... And Capital Books downtown... And of course Tattered Cover Books...which has three super stores in the Denver area...including the flagship store at the end of the 16th Street Mall. I might even look up John Dunnings old store in the 6300 block of Colfax Ave...Old Algonquin Books. Dunning being the author of Bookman's Wake and other Janeway mystery books that have a bookseller/bookscout theme...
In Salt Late I go to Sam Weller's... In Detroit it's John King... In Ann Arbor there are many great used and rare bookstores...Dawn Trader, Westside Books, and David's to hit the high points...